منابع مشابه
Markets for Product Modification Information
An important product strategy for firms in mature markets is value-adding modifications to existing products. Marketing information that reveals consumers’ preferences, buying habits, and lifestyle is critical for the identification of such product modifications. We consider two types of valueadding modifications that are often facilitated by marketing information: retention-type modifications ...
متن کاملAdvanced glycation end product modification of bone proteins and bone remodelling: hypothesis and preliminary immunohistochemical findings.
BACKGROUND The process of bone remodelling is disturbed in the development of osteoporosis. OBJECTIVE To investigate if proteins in osteoporotic bone are modified by advanced glycation end products (AGEs), and whether these alterations are related to measures of bone remodelling based on histomorphometric findings. METHODS Bone specimens taken from the iliac crest by bone biopsy of eight os...
متن کاملThe hypolipidemic natural product Commiphora mukul and its component guggulsterone inhibit oxidative modification of LDL.
There is accumulating evidence that LDL oxidation is essential for atherogenesis, and that antioxidants that prevent this oxidation may either slow down or prevent atherogenesis. In the present study, we found that Commiphora mukul and its cholesterol-lowering component, guggulsterone, effectively inhibited LDL oxidation mediated by either catalytic copper ions, free radicals generated with the...
متن کاملThe anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine
Phenotypic screens allow the identification of small molecules with promising anticancer activity, but the difficulty in characterizing the mechanism of action of these compounds in human cells often undermines their value as drug leads. Here, we used a loss-of-function genetic screen in human haploid KBM7 cells to discover the mechanism of action of the anticancer natural product ophiobolin A ...
متن کاملAdvanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells
Diabetic retinopathy (DR) is a major cause of adult blindness. Retinal Müller cells maintain water homeostasis and potassium concentration via inwardly rectifying Kir4.1 channels. Accumulation of advanced glycation end products (AGEs) is a major pathologic event in DR. While diabetes leads to a decrease in the Kir4.1 channels, it remains unknown whether AGEs-linked to the basement membrane (BM)...
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ژورنال
عنوان ژورنال: British Medical Bulletin
سال: 1996
ISSN: 0007-1420,1471-8391
DOI: 10.1093/oxfordjournals.bmb.a011526